Me--right knee has no cartilage between the kneecap and the femur. Left has deteriorated meniscus. I'm allergic to strong anti inflammatories. Diclonefac (Voltaren) gives me hives, but both the oral and the gel (C$18 in Canada) work great. Meloxicam (Mobic) gives me a skin rash but works great. Celebrex would probably trigger an allergic reaction in me. Orthovisc (synthetic oil for the knee, similar to Synvisc) worked great in the right for 12 or 13 months for five years, then it didn't work. Euflexxa (different synthetic) didn't work at that time, either. Cortisone works in the left's deteriorated meniscus, no help in the right's patella-femoral arthritis. I combined naproxen (Aleve) with acetaminophen (Tylenol) for a long time. No problem to combine them; each may have their own problems. Worked, but not strong enough. Tumeric plus SAM-e works about the same as the naproxen, easier on the gut, costs a lot more. Glucosamine & chondroitin were no help to me. Total joint replacements aren't 100% effective for everyone, and my knees aren't bad enough to take the risk. Partial knee replacements don't have a very good track record, I've heard. Two saw bones have each recommended that after a total knee replacement the skiing level is dialed way back. Breaking the bones the replacement attaches to can be permanently crippling.
My next step is bone marrow stem cell injections into the knees to re-grow cartilage. That was done by Dr. Mark Wagner, M.D., in Seattle the first of July. He takes a large blood draw to centrifuge into platelet rich plasma (PRP), extracts bone marrow from the hip bones and centrifuges to concentrate the stem cells, and extracts some fat tissue. He says the stem cells can grow to become any type of damaged tissue (cartilage or ligament), the processed fat acts like a matrix for the growth, and the PRP nourishes it. The whole process takes about 1-1/2 hours in the day surgery center. It's about a 20-25 cc injection into each knee, and it took several days to just get over that. Five weeks now, and I can tell something good is happening. Walking or light cycling are good, and I can do either with less discomfort as each week progresses. It is at least a 3 month process. I must not stress the knees; the cartilage must be allowed to grow. A couple of local chiropractors are advertising stem cell injections in the newspaper, but they use stem cells from amniotic fluid--from placentas. After treatment to the fluid to prevent transmission of disease, the stem cells are dead. The injections contain some growth factors that may help for a few months. The chiros hire a nurse-practitioner for a day to do the injections; chiros aren't licensed to give injections.
Pete--Consider all the choices for treatment listed by all the postings in order of cost, inconvenience, risk of bad outcomes, what your doc thinks will work for you. Many things help, and every individual is different. My local orthopod is doing PRP injections into his own knees. That can offer some help. This orthopedic surgeon is considering stem cell injections into his knees subject to what he learns from my experience--I'm his crash test dummy. A good source for information is the Arthritis Foundation (as you read the articles keep in mind the three types of arthritis--osteoarthritis (you & me), rheumatoid arthritis, and psoriatic arthritis, different problems, different solutions). The People's Pharmacy has info about natural remedies that do offer some help, but none offer strong help.
http://www.arthritis.org/about-arthritis/types/osteoarthritis/